منابع مشابه
Upstream and downstream of mTOR.
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of downstream targets. Some of the targets are phosphorylated directly by TOR, but many are phosphory...
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The mesoderm of the amphibian embryo is formed through an inductive interaction in which cells of the vegetal hemisphere of the embryo act on overlying equatorial cells. My laboratory is studying the Brachyury gene, which plays a key role in this interaction, being both necessary and sufficient for normal mesoderm formation. In this article I describe our attempts to understand how Xenopus Brac...
متن کاملUpstream and Downstream Influence on Stbli Unsteadiness
Direct numerical simulation data of a 24 compression ramp configuration are used to analyze the shock motion. The characteristic frequencies in the incoming boundary layer are reported for reference. The shock wave motion exhibits high-frequency spanwise wrinkling, as well as low-frequency streamwise motion. Correlations between the incoming flow and the shock motions, as well as the downstream...
متن کاملDownstream control of upstream open reading frames.
Department of Environmental and Biomolecular Systems, Oregon Health and Science University, Beaverton, Oregon 97006, USA; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97201, USA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA; Department of Microbiology and De...
متن کاملBlur the Boundary Between Upstream and Downstream
Cementing systems using ultra-lightweight hollow spheres can improve lightweight cement performance in deepwater operations and provide a viable alternative to conventional lightweight cement slurries. Efforts to expand the temperature limits of MWD and LWD tools have seen limited success. New approaches may be necessary if industry is to meet the demand for gas from deep reservoirs. Mixing fra...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2004
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm1458